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Armodafinil and modafinil both work well to increase wakefulness, however they vary in a few ways. The more refined form of modafinil is called armodafinil, which is its R-enantiomer. Its higher half-life results in longer-lasting benefits, and it could provide a more consistent, longer-lasting wakefulness boost with fewer alertness peaks and troughs. In contrast, modafinil may have a somewhat earlier onset but a potentially higher rate of withdrawal. Both medications are quite equal in terms of efficacy, with armodafinil being chosen for its longer-lasting effects. Individual requirements and responses will determine which option is best for them; some people may find one to be more acceptable or effective than the other. A healthcare professional should always be consulted for tailored advice.

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